Onatasertib
Product Specifications
CAS Number
1228013-30-6
Target
Apoptosis, DNA-PK, FLT, mTOR, c-Fms, PI3K
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, PI3K/Akt/mTOR signaling, Apoptosis, DNA Damage/DNA Repair
Purity
0.9993
Bioactivity
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Onatasertib is a potent mTOR kinase inhibitor (IC50: 16 nM), with >150-fold sensitivity than the related lipid kinase PI3Kα (IC50: 4 μM) .
Smiles
CO[C@H]1CC[C@@H](CC1)N1C(=O)CNc2ncc(nc12)-c1ccc(nc1)C(C)(C)O
Molecular Formula
C21H27N5O3
Molecular Weight
397.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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