Rg3039
Product Specifications
CAS Number
1005504-62-0
Target
Others, DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair
Purity
0.9958
Bioactivity
Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
Smiles
Nc1nc(N)c2c(OCC3CCN(Cc4c(Cl)cccc4Cl)CC3)cccc2n1
Molecular Formula
C21H23Cl2N5O
Molecular Weight
432.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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