SZL P1-41
Product Specifications
CAS Number
222716-34-9
Target
Apoptosis, E1/E2/E3 Enzyme
Related Pathways
Apoptosis, Ubiquitination
Purity
>99.99%
Bioactivity
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines.
Smiles
CCc1cc2c(occ(-c3nc4ccccc4s3)c2=O)c(CN2CCCCC2)c1O
Molecular Formula
C24H24N2O3S
Molecular Weight
420.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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