SZL P1-41
Product Specifications
CAS Number
222716-34-9
Target
Apoptosis, E1/E2/E3 Enzyme
Related Pathways
Apoptosis, Ubiquitination
Purity
>99.99%
Bioactivity
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines.
Smiles
CCc1cc2c(occ(-c3nc4ccccc4s3)c2=O)c(CN2CCCCC2)c1O
Molecular Formula
C24H24N2O3S
Molecular Weight
420.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![5-{[2-(6-Amino-9H-purin-9-yl)ethyl]amino}-1-pentanol](https://cdn.genprice.uk/products/572/6471876675618/imageurl/trc-a628913-1g.webp)
TRC-A628913-1G 1 g
5-{[2-(6-Amino-9H-purin-9-yl)ethyl]amino}-1-pentanol
Sign In for Pricing
View Details 
TRC-S561235-25MG 25 mg
(2R)-1-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-3-(stearoyloxy)propan-2-yl (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate
Sign In for Pricing
View Details 
AP23580PU-N 50 µL
Arginase 1 (ARG1) (1-145) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details ![UBA52 Mouse Monoclonal Antibody [Clone ID: OTI1C6]](https://cdn.genprice.uk/products/937/68dd18b8061270361e907c60/imageurl/cf805019.webp)
