ZG-2291

ZG-2291 is a selective inhibitor targeting FIH (Factor Inhibiting HIF) with oral activity. By binding to FIH, ZG-2291 promotes a conformational flip of a catalytically important tyrosine, enabling selective inhibition of FIH without affecting other 2OG oxygenases in the JmjC subfamily. ZG-2291k enhances thermogenesis in ob/ob mice and improves obesity-related symptoms and metabolic dysfunctions. ZG-2291 holds promise for research in the field of obesity-related diseases[1].

Product Specifications

CAS Number

[2962103-40-6]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/zg-2291.html

Purity

98.08

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CNC(C1=NC=C(C2=CC(C3=CC=CC(Cl)=C3)=NO2)C=C1O)=O

Molecular Formula

C17H12ClN3O5

Molecular Weight

373.75

References & Citations

[1]Wu Y, et al. A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity. Angew Chem Int Ed Engl. 2024 Jun 26:e202410438.