PF-04418948
Product Specifications
CAS Number
1078166-57-0
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein, Immunology/Inflammation
Purity
0.9945
Bioactivity
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors) . Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM) .
Smiles
COc1ccc2cc(OCC3(CN(C3)C(=O)c3ccc(F)cc3)C(O)=O)ccc2c1
Molecular Formula
C23H20FNO5
Molecular Weight
409.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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