Xevinapant hydrochloride
Product Specifications
CAS Number
1071992-57-8
Target
IAP, Apoptosis
Related Pathways
Apoptosis
Bioactivity
Xevinapant hydrochloride (AT-406 HCl), an orally active antagonist of multiple inhibitor of apoptosis proteins (IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide.
Smiles
Cl.[H][C@]12CC[C@H](N1C(=O)[C@H](CN(CC2)C(=O)CC(C)C)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1
Molecular Formula
C32H44ClN5O4
Molecular Weight
598.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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