IWP-051
Product Specifications
CAS Number
1354041-91-0
Target
Others, Guanylate cyclase
Related Pathways
Others, GPCR/G Protein
Bioactivity
IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM) . IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.
Smiles
C(N1C(=CC(=N1)C=2NC(=O)C(F)=CN2)C=3C=CON3)C4=C(F)C=CC=C4
Molecular Formula
C17H11F2N5O2
Molecular Weight
355.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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