GSK321
Product Specifications
CAS Number
1816331-63-1
Target
Dehydrogenase, Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolism
Purity
0.9973
Bioactivity
GSK321 is a selective and potent mutant isocitrate dehydrogenase 1 (IDH1) inhibitor that inhibits lipid synthesis and blocks cell proliferation in OPA1-deficient MEFs and prevents cytoplasmic glutamine reductive carboxylation.GSK321 has been used in the study of leukemia.
Smiles
C(N1C2=C(C(C(NC3=CC([C@H](C)O)=CC=C3)=O)=N1)CN(C(=O)C4=CC=CN4)C[C@H]2C)C5=CC=C(F)C=C5
Molecular Formula
C28H28FN5O3
Molecular Weight
501.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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