GSK256471
Product Specifications
CAS Number
1133706-08-7
Target
Others
Related Pathways
Others
Bioactivity
GSK256471 is a potent selective NK (3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK (3) receptors. In vitro functional assessment showed that GSK256471 reduced the E (Max) response induced by neurokinin B, indicating insurgable antagonist pharmacology (PA (2) =9.2) . GSK256471 may be a promising candidate for the treatment of schizophrenia.
Smiles
C(N(S(C)(=O)=O)C)C1=C(C(N[C@@H]([C@@H]2CC2)C3=CC=CC=C3)=O)C4=C(N=C1C5=CC=CC=C5)C=CC=C4
Molecular Formula
C29H29N3O3S
Molecular Weight
499.62
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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