MK-571 sodium
Product Specifications
CAS Number
115103-85-0
Target
LTR, Leukotriene Receptor, LPL Receptor, P-gp
Related Pathways
GPCR/G Protein, Immunology/Inflammation, Membrane transporter/Ion channel, Neuroscience
Purity
0.9958
Bioactivity
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM) . MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
Smiles
[Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Molecular Formula
C26H27ClN2O3S2·Na
Molecular Weight
537.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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