Uridine triphosphate-15N2 (dilithium)

Uridine triphosphate-15N2 (UTP-15N2 dilithium; Uridine 5'-triphosphate-15N2) dilithium is 15N labeled Uridine triphosphate (HY-107372) . Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

Product Specifications

Product Name Alternative

UTP-15N2 (dilithium) ; Uridine 5'-triphosphate-15N2 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/uridine-triphosphate-15n2-dilithium.html

Concentration

100 mM in 200.80 μL Tris HCl buffer pH=7.5

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C([15N]1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O)(O[Li])=O)(O[Li])=O)=O)O2)[15NH]C(C=C1)=O

Molecular Formula

C9H13Li2 15N2O15P3

Molecular Weight

497.99

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9 (6) :e98998.|[3]Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42 (4) :680-6.|[4]Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72 (8) :949-55.|[5]Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice. Microbes Infect. 2014 Mar;16 (3) :196-202.