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(R) -HTS-3

Selected Variant

HY-158790-01

Size: 1 mg

(R) -HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R) -HTS-3 suppresses the C20:4 content of PE, PC, and PS, while promoting a correspondingelevation in C22:4 phospholipids and a paradoxical increase in C20:4 phosphatidylinositol (PI) lipids[1].

Product Specifications

CAS Number

2771208-83-2

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-hts-3.html

Purity

99.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(F)=CC(F)=C1)NC[C@@H](C2=CC=CC=C2)N(C)C

Molecular Formula

C17H18F2N2O

Molecular Weight

304.33

References & Citations

[1]Alex Reed, et al. LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis. ACS Chem Biol. 2022 Jun 17;17 (6) :1607-1618.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Price

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