(R)-HTS-3
Product Specifications
UNSPSC Description
(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R)-HTS-3 suppresses the C20:4 content of PE, PC, and PS, while promoting a correspondingelevation in C22:4 phospholipids and a paradoxical increase in C20:4 phosphatidylinositol (PI) lipids[1].
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-hts-3.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(F)=CC(F)=C1)NC[C@@H](C2=CC=CC=C2)N(C)C
Molecular Weight
304.33
References & Citations
[1]Alex Reed, et al. LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis. ACS Chem Biol. 2022 Jun 17;17(6):1607-1618.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158790/R-HTS-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158790/R-HTS-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2771208-83-2
Available Sizes
Curated Selection
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