Pyridone 6
Product Specifications
CAS Number
457081-03-7
Target
JAK, Tyrosine Kinases
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Stem Cells, Chromatin/Epigenetic
Purity
0.9874
Bioactivity
Pyridone 6 (JAK Inhibitor) (CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM) ; displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.
Smiles
CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O
Molecular Formula
C18H16FN3O
Molecular Weight
309.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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