Valsartan methyl ester
Valsartan (CGP 48933) methyl ester is the methyl ester derivative of Valsartan (HY-18204) . Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure[1].
Product Specifications
CAS Number
[137863-17-3]
Product Name Alternative
CGP 48933 methyl ester
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
Angiotensin Receptor; Drug Derivative
Type
Reference compound
Related Pathways
GPCR/G Protein; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/valsartan-methyl-ester.html
Purity
99.39
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
COC([C@H](C(C)C)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2)=O
Molecular Formula
C25H31N5O3
Molecular Weight
449.55
Precautions
H228, H315, H319
References & Citations
[1]Stanko P, et al. Sacubitril/Valsartan Alleviates Cardiac Remodeling and Dysfunction in L-NAME-Induced Hypertension and Hypertensive Heart Disease.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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