Droperidol

Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist that inhibits the activation of GABA (A) and neuronal nicotinic receptors (nAChR), with IC50 values of 12.6 nM and 5.8 μM. Droperidol has anesthetic and sedative properties[1][2].

Product Specifications

CAS Number

[548-73-2]

Product Name Alternative

Dehydrobenzperidol

UNSPSC

12352005

Hazard Statement

H302

Target

Dopamine Receptor; GABA Receptor; nAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Droperidol.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1NC2=CC=CC=C2N1C3=CCN(CCCC(C4=CC=C(F)C=C4)=O)CC3

Molecular Formula

C22H22FN3O2

Molecular Weight

379.43

Precautions

H302

References & Citations

[1]Pamela Flood, et al. Droperidol inhibits GABA (A) and neuronal nicotinic receptor activation. Anesthesiology. 2002 Apr;96 (4) :987-93. |[2]J YELNOSKY, et al. A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF DROPERIDOL. Toxicol Appl Pharmacol. 1964 Jan:5:37-47.