Atecegatran metoxil
Product Specifications
CAS Number
433937-93-0
Target
Others|||Thrombin
Related Pathways
Proteases/Proteasome|||Others
Bioactivity
Atecegatran Metoxil (Atecegatran Fexenetil , AZD0837) is an oral direct thrombin inhibitor, which currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. AZD0837 is a selective and reversible direct thrombin inhibitor and is a bioconverted to AR-H067637.AZD0837 is well tolerated in healthy male subjects at a single oral dose (15-750 mg) and demonstrated favorable PK properties and reproducible effects on in vitro coagulation time variables, supporting further clinical development.
Smiles
C([C@H](O)C1=CC(OC(F)F)=CC(Cl)=C1)(=O)N2[C@H](C(NCC3=CC=C(C(NOC)=N)C=C3)=O)CC2
Molecular Formula
C22H23ClF2N4O5
Molecular Weight
496.89
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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