NFAT Inhibitor-1

NFAT Inhibitor (VIVIT peptide) is an inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].

Product Specifications

CAS Number

[249537-73-3]

Product Name Alternative

VIVIT peptide

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Nuclear Factor of activated T Cells (NFAT)

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NFAT_Inhibitor.html

Purity

99.89

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(CCC1)C(CNC([C@H](C)NC([C@@H](N)CCSC)=O)=O)=O)N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(NCC(N4[C@@H](CCC4)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C75H118N20O22S

Molecular Weight

1683.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285 (5436) :2129-33.|[2]Ma JD, et al. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Aug;71 (8) :1252-1264.