AKB-6899
Product Specifications
CAS Number
1007377-55-0
Target
HIF/HIF Prolyl-Hydroxylase|||VEGFR|||HIF
Related Pathways
Chromatin/Epigenetic|||Angiogenesis|||Metabolism|||Tyrosine Kinase/Adaptors
Purity
0.9787
Bioactivity
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2? which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.
Smiles
OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1
Molecular Formula
C14H11FN2O4
Molecular Weight
290.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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