ZLD1039
Product Specifications
CAS Number
1826865-46-6
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.9982
Bioactivity
ZLD1039 is a potent, orally bioavailable EZH2 (Enhancer of Zeste Homolog 2) inhibitor with high selectivity. It demonstrates strong, concentration-dependent inhibition of both wild-type and mutant (Y641F and A677G) PRC2 (Polycomb Repressive Complex 2) enzymatic activities, exhibiting IC50 values of 5.6, 15, and 4.0 nM, respectively. Additionally, ZLD1039 effectively suppresses breast tumor growth and metastasis.
Smiles
CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1
Molecular Formula
C36H48N6O3
Molecular Weight
612.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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