Upacicalcet
Product Specifications
CAS Number
1333218-50-0
Target
Calcium Channel, CaSR
Related Pathways
GPCR/G Protein, Metabolism, Membrane transporter/Ion channel
Purity
0.9988
Bioactivity
Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.
Smiles
N(C(NC[C@@H](C(O)=O)N)=O)C1=CC(S(=O)(=O)O)=CC(Cl)=C1C
Molecular Formula
C11H14ClN3O6S
Molecular Weight
351.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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