TP-064
Product Specifications
CAS Number
2080306-20-1
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.9907
Bioactivity
TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.
Smiles
CNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1
Molecular Formula
C28H34N4O2
Molecular Weight
458.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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