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TP-064

Product Specifications

CAS Number

2080306-20-1

Target

Histone Methyltransferase

Related Pathways

Chromatin/Epigenetic

Purity

0.9907

Bioactivity

TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.

Smiles

CNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1

Molecular Formula

C28H34N4O2

Molecular Weight

458.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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