Tigilanol tiglate
Product Specifications
CAS Number
943001-56-7
Target
PKC, Caspase
Related Pathways
Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis, Cytoskeletal Signaling
Bioactivity
Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate promotes mitochondrial/endoplasmic reticulum dysfunction, leading to ATP depletion, caspase activation, and gasdermin E cleavage. It induces immunogenic cell death, enhancing the response to immune checkpoint blockade in both target tumours and non-injected tumours, resulting in tumour regression.
Smiles
O(C([C@H](CC)C)=O)[C@@]12[C@@](C1(C)C)([C@@]3([C@]4([C@](CO)(O4)[C@@H](O)[C@@]5(O)[C@]([C@@]3(O)[C@H](C)[C@H]2OC(/C(=C/C)/C)=O)(C=C(C)C5=O)[H])[H])[H])[H]
Molecular Formula
C30H42O10
Molecular Weight
562.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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