T-1095A

T-1095A is an active metabolite of T-1095, a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs) . Chronic administration of T-1095 (0.1% w w (-1) pellet chow, for 12 weeks) decreased blood glucose and haemoglobin A (1C) levels, and improved glucose intolerance in db/db mice. Long-term treatment with T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki Rats.