SX-517
Product Specifications
CAS Number
1240494-13-6
Target
CXCR
Related Pathways
GPCR/G Protein, Immunology/Inflammation, Autophagy
Bioactivity
SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca2+ flux (IC50 = 38 nM), antagonises CXCL-8-induced [ (35) S]GTPγS binding (IC50 = 60 nM), and suppresses ERK1/2 phosphorylation.
Smiles
O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2
Molecular Formula
C19H16BFN2O3S
Molecular Weight
382.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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