SKI2496
Product Specifications
CAS Number
1308378-95-1
Target
ERK|||Others|||GNRH Receptor
Related Pathways
GPCR/G Protein|||Others|||MAPK
Bioactivity
SKI2496 is a potent and orally bioavailableantagonist of Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM; max. LH inh. inh. (%, h) = 84%, 12h; LH inh. (24h) = 76%.) . SKI2496 exhibits more selective antagonistic activity toward the human GnRH receptors over the GnRHRs in monkeys and rats.
Smiles
CC1=C(C(=O)N(C[C@H](NCCCC(O)=O)C2=CC=CC=C2)C(=O)N1CC3=C(C(F)(F)F)C=CC=C3F)N4CCN(CC=5OC(C(F)(F)F)=CC5)CC4
Molecular Formula
C35H36F7N5O5
Molecular Weight
739.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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