REDX05358
Product Specifications
CAS Number
1884226-20-3
Target
Raf, Others
Related Pathways
Others, MAPK
Bioactivity
REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors. REDX05358 has improved therapeutic potential and predicted safety profile. REDX05358 demonstrates subnanomolar binding affinity for BRAF and CRAF with high selectivity profile against a panel of 468 kinases that exhibits negligible paradoxical activation due to inhibition of both RAF monomers and dimers.
Smiles
O(C=1C=C2C(OCC(C2)C=3NC(=CN3)C4=C(Cl)C=CC=C4)=CC1)C5=C6C(NC=C5)=NC(=O)CC6
Molecular Formula
C26H21ClN4O3
Molecular Weight
472.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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