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R-82913

Product Specifications

CAS Number

126347-69-1

Target

Others, DNA/RNA Synthesis, Reverse Transcriptase, HIV Protease

Related Pathways

Proteases/Proteasome, Microbiology/Virology, DNA Damage/DNA Repair, Others, Cell Cycle/Checkpoint

Bioactivity

R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold more potent than AZT-TP in the inhibition of HIV-1 reverse transcriptase in an assay. R82913 has no effect on the replication of HIV-2 in CEM cells and does not inhibit the reverse transcriptase from this virus.

Smiles

S=C1N2C3=C(CN(CC=C(C)C)[C@@H](C)C2)C=C(Cl)C=C3N1

Molecular Formula

C16H20ClN3S

Molecular Weight

321.87

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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