R-82913
Product Specifications
CAS Number
126347-69-1
Target
Others|||DNA/RNA Synthesis|||Reverse Transcriptase|||HIV Protease
Related Pathways
Proteases/Proteasome|||Microbiology/Virology|||DNA Damage/DNA Repair|||Others|||Cell Cycle/Checkpoint
Bioactivity
R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold more potent than AZT-TP in the inhibition of HIV-1 reverse transcriptase in an assay. R82913 has no effect on the replication of HIV-2 in CEM cells and does not inhibit the reverse transcriptase from this virus.
Smiles
S=C1N2C3=C(CN(CC=C(C)C)[C@@H](C)C2)C=C(Cl)C=C3N1
Molecular Formula
C16H20ClN3S
Molecular Weight
321.87
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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