PF-6422899

1621002-23-0

Others|||EGFR

Tyrosine Kinase/Adaptors|||Others|||Angiogenesis|||JAK/STAT signaling

PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.

N(C=1C2=C(C=C(OCC#C)C(NC(C=C)=O)=C2)N=CN1)C3=CC(Cl)=C(F)C=C3

C20H14ClFN4O2

396.8

Cool pack

-20°C