PF-5274857 mseylate (1373615-35-0 free base)
Selected Variant
T28388-01
Size: 25 mg
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates.
Smiles
O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O.OS(=O)(C)=O
Molecular Formula
C21H29ClN4O6S2
Molecular Weight
533.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Price
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