PD 136450
Product Specifications
CAS Number
139067-52-0
Target
Others, Cholecystokinin Receptor
Related Pathways
GPCR/G Protein, Others
Bioactivity
Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B) ) receptor antagonists may help to elucidate the physiological role of gastrin, have therapeutic potential as acid antisecretory drugs, and may be of use as adjuvant therapy for gastrin sensitive tumours. The agonist effect of PD-136,450 is mediated via interaction with the gastrin (CCK-B) receptor in the stomach and the CCK-A receptor in the pancreas.
Smiles
O(C(N[C@](CC=1C=2C(NC1)=CC=CC2)(C(NC[C@H](NC(C=CC(O)=O)=O)C3=CC=CC=C3)=O)C)=O)[C@H]4[C@@]5(CC6(C[C@]4(CC(C5)(C6)[H])[H])[H])[H]
Molecular Formula
C35H40N4O6
Molecular Weight
612.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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