Pamiparib maleate
Product Specifications
CAS Number
2086689-94-1
Target
Others, Apoptosis
Related Pathways
Apoptosis, Others
Bioactivity
Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis.
Smiles
OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34.C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34
Molecular Formula
C44H42F2N8O14
Molecular Weight
944.859
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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