Crocin

Product Specifications

CAS Number

42553-65-1

Target

Endogenous Metabolite|||Others|||JAK|||Apoptosis

Related Pathways

Angiogenesis|||Others|||Stem Cells|||Chromatin/Epigenetic|||Metabolism|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Apoptosis

Purity

0.9927

Bioactivity

Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L.) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Crocin suppresses tumor necrosis factor (TNF) alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase.

Smiles

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