NT113
Product Specifications
CAS Number
1398833-56-1
Target
Others
Related Pathways
Others
Bioactivity
NT113 is a pan-ERBB inhibitor with high brain penetrance. NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. NT113 inhibits the growth of glioblastoma xenografts with EGFR amplification. NT113 has inhibitory activity, both in vivo and in vitro, on ERBB family member phosphorylation, as well as on the phosphorylation of downstream signaling mediator Akt.
Smiles
C(#CC=1C(NC(/C=C/CN(C)C)=O)=CC2=C(C1)N=CN=C2NC3=CC(Cl)=C(F)C=C3)[C@@H]4[C@@]5([C@]4(COC5)[H])[H]
Molecular Formula
C27H25ClFN5O2
Molecular Weight
505.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MR208859L3V 200 µL
Slc1a7 (NM_146255) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details 
RFB-25-850 1 mL
DiagNano™ Biotin Gold Nanorods, diameter 25 nm, absorption max 850 nm
Sign In for Pricing
View Details