Amaroswerin

Amaroswerin is a bioactive secoiridoid glucoside from Swertia mussotii. Amaroswerin has anti-inflammatory, antidiabetic, antiviral, anticholinergic and immunomodulatory activities. Amaroswerin inhibits NO release with an IC50 value of 5.42 μg/mL in RAW264.7 cells[1].

Product Specifications

CAS Number

[21233-18-1]

UNSPSC

12352005

Target

NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/amaroswerin.html

Purity

98.78

Solubility

10 mM in DMSO

Smiles

C=C[C@@H]1[C@]2(C(C(OCC2)=O)=CO[C@H]1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC(C4=C(C5=CC(O)=CC=C5)C=C(C=C4O)O)=O)O

Molecular Formula

C29H30O14

Molecular Weight

602.54

References & Citations

[1]Yuan Xiang, et al. Anti-inflammatory activity of compounds isolated from Swertia mussotii. Nat Prod Res. 2019 Feb;33 (4) :598-601.|[2]Satyendra Suryawanshi, et al. Assessment of systemic interaction between Swertia chirata extract and its Bioactive constituents in rabbits. Phytother Res. 2009 Jul;23 (7) :1036-8.