MS2177
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20) . MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillation proximity assay. Binding of MS2177 to SETD8 was confirmed by isothermal titration calorimetry (ITC), having a KD of 1.3 μM.
Smiles
COC1=C(OCCN)C=C(N=C(N2CCCC2)N=C3NCCCCCN4CCCC4)C3=C1
Molecular Formula
C24H38N6O2
Molecular Weight
442.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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