Monocrotaline
Product Specifications
CAS Number
315-22-0
Target
TGF-beta/Smad
Related Pathways
Stem Cells
Purity
0.9994
Bioactivity
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid extracted from the seeds of Crotalaria plants. It inhibits organic cation transporters OCT-1 and OCT-2, with IC50 values of 36.8 μM and 1.8 mM, respectively. Monocrotaline exhibits antitumor activity and shows certain cytotoxicity against liver cancer cells such as HepG2. It is also commonly used to induce pulmonary arterial hypertension models in rodents.
Smiles
C[C@H]1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]1(C)O)C23
Molecular Formula
C16H23NO6
Molecular Weight
325.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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