Aristolochic acid A
Product Specifications
CAS Number
313-67-7
Target
NF-κB
Related Pathways
NF-κB
Purity
0.9997
Bioactivity
Aristolochic acid A is the main component of the plant extract aristolochic acids, primarily found in the herbaceous plants Aristolochia and Asarum. It significantly inhibits the activity of activator protein 1 (AP-1) and NF-κB, and downregulates the expression of the bladder cancer-associated BLCAP gene in human cells. It is commonly used to induce nephrotoxicity models.
Smiles
COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O
Molecular Formula
C17H11NO7
Molecular Weight
341.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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