Manzamine A
Product Specifications
CAS Number
104196-68-1
Target
Others, Parasite, HSV, Autophagy, GSK-3, Proton pump, CDK
Related Pathways
Autophagy, PI3K/Akt/mTOR signaling, Microbiology/Virology, Membrane transporter/Ion channel, Others, Stem Cells, Cell Cycle/Checkpoint
Bioactivity
Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, and decreases tau hyperphosphorylation.
Smiles
[H][C@]12C[C@]34C[N@@]5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCCC=C2)c1nccc2c3ccccc3[nH]c12 |w:29.32,c:11,17|
Molecular Formula
C36H44N4O
Molecular Weight
548.775
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6289678-01 0.1 mL
CTBP1, CT (CTBP1, CTBP, C-terminal-binding protein 1) (MaxLight 550)
Sign In for Pricing
View Details MBS6289678-02 5x 0.1 mL
CTBP1, CT (CTBP1, CTBP, C-terminal-binding protein 1) (MaxLight 550)
Sign In for Pricing
View Details 
orb498434 100 µL
Complement component C9a Rabbit Polyclonal Antibody (PE)
Sign In for Pricing
View Details