K-14585
Product Specifications
CAS Number
880546-17-8
Target
P38 MAPK, NF-κB, Protease-activated Receptor, Others
Related Pathways
MAPK, Others, NF-κB, GPCR/G Protein
Bioactivity
K-14585 is a proteinase-activated receptor 2 antagonist. K-14585 inhibited PAR (2) -mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8.
Smiles
C(C=1C=2C(N(CC3=C(Cl)C=CC=C3Cl)C1)=CC=C(NC(NCC(N[C@H](C(N[C@H](C(NC(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CCCCN)=O)=O)C2)N7CCCC7
Molecular Formula
C51H56Cl2N8O4
Molecular Weight
915.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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