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CCR2 antagonist 5

Product Specifications

CAS Number

1228650-83-6

Target

CCR

Related Pathways

GPCR/G Protein, Microbiology/Virology, Immunology/Inflammation

Purity

0.9998

Bioactivity

CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM) .JNJ-41443532 binds mCCR2 with a Ki of 9.6 μM, which can be used to study inflammatory diseases and diabetes. diseases and diabetes.

Smiles

N(C(CNC(=O)C1=CC(C(F)(F)F)=CC=C1)=O)C2CN([C@@H]3CC[C@@](O)(CC3)C4=CN=CS4)C2

Molecular Formula

C22H25F3N4O3S

Molecular Weight

482.52

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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