NOD2 antagonist 1

NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP) -induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1].

Product Specifications

CAS Number

[2411441-54-6]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nod2-antagonist-1.html

Purity

99.57

Solubility

DMSO : 35.71 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC2=C(CCC2)C=C1)CN3C4=CC=CC=C4N=C3CCNS(=O)(C5=CC=CC=C5)=O

Molecular Formula

C26H26N4O3S

Molecular Weight

474.57

References & Citations

[1]Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NOD2

Available Sizes

Curated Selection

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