GSK-2250665A
Product Specifications
CAS Number
1246030-96-5
Target
Tyrosine Kinases
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.9938
Bioactivity
GSK-2250665A is an interleukin-2-inducible T-cell kinase (Itk) inhibitor with a binding affinity of pKi = 9.2, GSK-2250665A demonstrates significant selectivity for Itk over Aurora B kinase and Bruton's tyrosine kinase (Btk), with pIC50 values of 6.4 and 6.5 respectively, while also showing limited activity against other kinases, and GSK-2250665A inhibits interferon-gamma (IFN?) production in peripheral blood mononuclear cells (PBMCs), establishing it as a highly selective chemical probe for T-cell receptor signaling research and immune modulation studies.
Smiles
N(C=1SC=2C(N1)=CC=C(CC)C2)C3=NC(N[C@H]4CC[C@H](O)CC4)=NC(CC5=CC=CC=C5)=C3
Molecular Formula
C26H29N5OS
Molecular Weight
459.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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