GSK1733953A
Product Specifications
CAS Number
930470-97-6
Target
Antibacterial
Related Pathways
Microbiology/Virology
Purity
0.9994
Bioactivity
GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 ± 0.6 ?M.GSK1733953A is a selective biphenylbenzamide with an inhibitory effect on the catalytic methylation of the Mycobacterium tuberculosis desmethylnaphthoquinone methyltransferase, and the MIC of GSK1733953A against Mycobacterium tuberculosis H4Rv was 8.37 ?g/ml. MIC of 8.37 ?g/ml and MIC of 1.2 to 9.6 ?g/ml against drug-resistant strains.GSK1733953A is a candidate compound for the treatment of tuberculosis.
Smiles
O(C)C1=C(C=C(NC(=O)C2=C(Cl)C=C(F)C=C2)C=C1)C3=CC=C(OC)C=C3
Molecular Formula
C21H17ClFNO3
Molecular Weight
385.82
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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