Olorofim
Product Specifications
CAS Number
1928707-56-5
Target
Dehydrogenase, Antifungal
Related Pathways
Microbiology/Virology, Metabolism
Purity
0.9928
Bioactivity
Olorofim (F-901318) is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM) .Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.
Smiles
C(C(NC1=CC=C(C=C1)N2CCN(CC2)C=3N=CC(F)=CN3)=O)(=O)C4=C(C=C(C)N4C)C5=CC=CC=C5
Molecular Formula
C28H27FN6O2
Molecular Weight
498.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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