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Ensaculin HCl

Product Specifications

CAS Number

209969-60-8

Target

Others, iGluR

Related Pathways

Neuroscience, Membrane transporter/Ion channel, Others

Bioactivity

Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD) . Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effects in primary cultured rat brain cells. In receptor-binding studies, ensaculin was found to have high affinities to serotonergic 5-HT (1A) and 5-HT (7) receptors, adrenergic alpha (1), and dopaminergic D (2) and D (3) receptors.

Smiles

Cl.O=C1OC=2C=C(OC)C(OCCCN3CCN(C=4C=CC=CC4OC)CC3)=CC2C(=C1C)C

Molecular Formula

C26H33ClN2O5

Molecular Weight

489

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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