Dezapelisib
Product Specifications
CAS Number
1262440-25-4
Target
Others, PI3K
Related Pathways
PI3K/Akt/mTOR signaling, Others
Bioactivity
Dezapelisib is an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) . INCB040093 prevents both the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in PI3K-overexpressing tumor cells.
Smiles
[C@H](NC1=C2C(N=CN2)=NC=N1)(C)C3=C(C(=O)N4C(=N3)SC=C4C)C5=CC(F)=CC=C5
Molecular Formula
C20H16FN7OS
Molecular Weight
421.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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