Crebinostat
Product Specifications
CAS Number
1092061-61-4
Target
Histone Acetyltransferase, Epigenetic Reader Domain, HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9949
Bioactivity
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, targeting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively. It increases the density of synapsin-1 punctae along dendrites in neurons in vitro, modulates chromatin-mediated neuroplasticity, and enhances memory in mice. Additionally, Crebinostat induces histone H3 and H4 acetylation and enhances the expression of Egr1, a cAMP-responsive element binding protein (CREB) target gene.
Smiles
C(=NNC(CCCCCC(NO)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2
Molecular Formula
C20H23N3O3
Molecular Weight
353.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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